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CD3 Mouse anti-Human, Brilliant Violet 711, Clone: UCHT1, BD

Mouse Monoclonal Antibody

$201.00 - $396.00

Specifications

Antigen CD3
Isotype IgG1, κ
Immunogen Human infant thymocytes and peripheral blood lymphocytes from a Sézary Syndrome donor
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Conjugate Brilliant Violet 711
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB563724
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BD Biosciences
563724
25 Tests
Each for $201.00
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BDB563725
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BD Biosciences
563725
100 Tests
Each for $396.00
Add to cart
 
Description

Description

The UCHT1 monoclonal antibody specifically binds to the human CD3 ε -chain, a 20-kDa subunit of the CD3/T cell antigen receptor complex. CD3 ε is expressed on 70-80% of normal human peripheral blood lymphocytes and 60-85% of thymocytes. Studies from the HLDA Workshop show that this antibody is mitogenic for CD3 ε -positive cells when used in conjunction with costimulatory agents such as pokeweed mitogen or anti-CD28 antibody. CD3 plays a central role in signal transduction during antigen recognition. The UCHT1 antibody stains both surface and intracellular CD3 ε unlike the other CD3 clone, HIT3a, that stains only extracellular CD3 ε .

The antibody was conjugated to BD Horizon™ BV711 which is part of the BD Horizon™ Brilliant Violet™ family of dyes. This dye is a tandem fluorochrome of BD Horizon™ BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 711-nm. BD Horizon™ BV711 can be excited by the violet laser and detected in a filter used to detect Cy™5.5 / Alexa Fluor™ 700-like dyes (eg, 712/20-nm filter). Due to the excitation and emission characteristics of the acceptor dye, there may be moderate spillover into the Alexa Fluor™ 700 and PerCP-Cy™5.5 detectors. However, the spillover can be corrected through compensation as with any other dye combination.

Specifications

Specifications

CD3
Human infant thymocytes and peripheral blood lymphocytes from a Sézary Syndrome donor
Brilliant Violet 711
Flow Cytometry
RUO
UCHT1
CD3e; CD3E; T3E; TCRE; T-cell surface antigen T3/Leu-4 epsilon
IgG1, κ
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Primary
Mouse
Affinity Purified
Monoclonal
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
SDS
Product Certifications

For Research Use Only.

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