CD31 Mouse anti-Human, BB515, Clone: WM59, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 564630
The WM59 monoclonal antibody specifically binds to platelet endothelial cell adhesion molecule-1, (PECAM-1, PECAM1), which is also known as GPIIA', or EndoCAM. CD31 is a 130 kDa type I transmembrane glycoprotein that belongs to the Ig gene superfamily. CD31 has wide tissue distribution and is expressed on platelets, monocytes, granulocytes, NK cells, T cell subsets, and in high amounts on endothelial cells. CD31 functions as a vascular endothelial cell adhesion molecule and is involved in the transendothelial migration of leucocytes in inflammatory responses. It may also be involved in thrombosis, angiogenesis, and wound healing.
The antibody was conjugated to BD Horizon BB515 which was developed exclusively by BD Biosciences. With an excitation max of 490nm and an emission max of 515nm, BD Horizon BB515 can be excited by the 488nm laser and detected in a standard FITC set (eg, 530/30-nm filter). This dye provides a much brighter alternative to FITC with less spillover into the PE detector.
|EndoCAM; GPIIA'; PECA1; PECAM1; Platelet endothelial cell adhesion molecule|
|Aqueous buffered solution containing ≤0.09% sodium azide|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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