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CD36 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527236

Catalog No. PIPA527236


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Description

Description

PA5-27236 targets CD36 in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples. The PA5-27236 immunogen is synthetic peptide corresponding to a region within amino acids 302 and 395 of Human CD36. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

CD36 (fatty acid translocase, FAT) is an 88 kDa, ditopic glycosylated protein that belongs to the class B family of scavenger receptors. CD36 is expressed by most resting marginal zone B cells but not by follicular and B1 B cells, and is rapidly induced on Follicular B cells in vitro upon TLR and CD40 stimulation. CD36 does not affect the development of B cells, but modulates both primary and secondary antibody response. Similar to glucose transporter GLUT4, CD36 is translocated from intracellular pools to the plasma membrane following cell stimulation by insulin. In mouse, CD36 is responsible for gustatory perception of long-chain fatty acids. CD36 is preferentially found within lipid rafts, which facilitates its association with receptors, signaling and adapter molecules. CD36 binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. Further, CD36 may function as a cell adhesion molecule and directly mediates cyto-adherence of Plasmodium falciparum parasitized erythrocytes. Mutations in the CD36 gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the CD36 protein have been found.
Specifications

Specifications

CD36
Polyclonal
Unconjugated
CD36
Liquid
CD36
Synthetic peptide corresponding to a region within amino acids 302 and 395 of Human CD36
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
0.47 mg/mL
PBS with 1% BSA, 20% glycerol and 0.025% Proclin 300; pH 7
P16671, Q08857
FAT, GPIV, Scarb3, GPIIIB, PAS IV, PAS-4, fatty acid translocase, glycoprotein IIIb, platelet glycoprotein 4, platelet glycoprotein IV
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
12491, 948
Documents
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