CD38 Mouse anti-Human, Clone: HIT2, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119316
CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. Another role of CD38 is provided by enzymatic activity of its extracellular part. CD38 acts as NAD+ glycohydrolase converting NAD+ into ADP-ribose, as ADP-ribosyl cyclase producing cADPR and as cADPR hydrolase, thus affecting levels of calcium-mobilizing metabolites. ADPR produced by CD38 serves as an important second messenger of neutrophil and dendritic cell migration.A suggested positive control for this product is RAJI human cells.
|PBS with 15mM sodium azide; pH 7.4|
|T10, ADP-ribosyl cyclase 1, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase, CD38 antigen p45, NAD+ nucleosidase, cADPr hydrolase 1, cyclic ADP-ribose hydrolase 1|
|4° C, do not freeze|
|Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot|
|Fetal human thymocytes.|
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