CD38 Mouse anti-Human, Clone: ICO-20, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA17653
MA1-7653 detects CD38 from human samples. MA1-7653 has been successfully used in flow cytometry procedures. The MA1-7653 immunogen is Hematopoietic precursors, thymocytes, activated T-cells and plasma cells. Store at 4°C short term. Store at -80°C long term.CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. CD38 functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ glycohydrolase or as a cell surface receptor. Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e. identification of myelomas), and as a marker for activated B and T cells. CD38 participates in cell adhesion, signal transduction and calcium signaling. Further, CD38 is expressed at high levels in the pancreas, liver, kidney, maligt lymphoma and neuroblastoma. Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter’s Syndrome.
|Hematopoietic precursors, thymocytes, activated T-cells and plasma cells.|
|PBS with 0.2% gelatin, 0.5% saccharose and 0.1% sodium azide|
|T10, ADP-ribosyl cyclase 1, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase, CD38 antigen p45, NAD+ nucleosidase, cADPr hydrolase 1, cyclic ADP-ribose hydrolase 3|
|4°C or -80°C if preferred|
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