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CD40 Rabbit anti-Canine, Guinea Pig, Hamster, Human, Mouse, Non-human primate, Ovine, Porcine, Rabbit, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA131075

Catalog No. PA131075


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Description

Description

PA1-31075 detects CD40 from rat, human, mouse, canine, guinea pig, hamster, non-human primate, porcine, rabbit, and sheep samples. PA1-31075 has been successfully used in Western blot applications. The PA1-31075 immunogen is: Synthetic peptide: CQPVTQEDGKESRISVQERQ conjugated to KLH, corresponding to amino acids 258-277 of Human CD40. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

The CD40 antigen is a single chain glycoprotein that is known to be a member of the tumor necrosis factor/nerve growth factor superfamily and shows a significant homology to the Hodgkin ft.s disease associated antigen, CD30. CD40 is present on all B cells except plasma cells and is also found on some epithelial cells, carcinomas and lymphoid dendritic cells. CD40 has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of CD40, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and serves as a mediator of the signal transduction. The interaction of CD40 and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of CD40 encoding distinct isoforms have been reported. Diseases associated with CD40 dysfunction include Type 3 Hyper-Igm immunodeficiency and CD40 ligand deficiency.
Specifications

Specifications

CD40
Polyclonal
Unconjugated
CD40
Liquid
CD40
synthetic peptide CQPVTQEDGKESRISVQERQ conjugated to KLH, corresponding to amino acids 258-277 of Human CD40.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Canine, Guinea Pig, Hamster, Human, Mouse, Non-human primate, Ovine, Porcine, Rabbit, Rat
Western Blot
1 mg/mL
PBS with 50% glycerol and 0.09% sodium azide
Q7YRL5, P25942, P27512, Q8SQ34
Bp50, CDW40, MGC9013, TNFRSF5, p50
Rabbit
IgG
50 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
100349106, 100728791, 100770242, 171369, 21939, 397395, 403469, 443232, 958
Documents
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