CD43 Rat anti-Mouse, BB515, Clone: S7, BD
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 564646
The S7 monoclonal antibody specifically binds to the 115 kDa glycosylated form of CD43 (Ly-48, Leukosialin). CD43 is expressed on IL-7-responsive pro-B cells, plasma cells, peritoneal and splenic CD5+ B cells (B-1 cells), granulocytes, monocytes, macrophages, platelets, natural killer cells, thymocytes, peripheral T cytotoxic/suppressor cells, and most T helper cells, but not resting conventional peripheral B cells. CD43 expression has also been detected on pluripotent hematopoietic stem cells and myeloid, lymphoid, and NK-cell progenitors in the bone marrow. Studies of CD43-deficient mice indicate that CD43 participates in the negative regulation of T-cell activation and adhesion.
The antibody was conjugated to BD Horizon BB515 which was developed exclusively by BD Biosciences. With an excitation max of 490nm and an emission max of 515nm, BD Horizon BB515 can be excited by the 488nm laser and detected in a standard FITC set (eg, 530/30-nm filter). This dye provides a much brighter alternative to FITC with less spillover into the PE detector.
|Aqueous buffered solution containing ≤0.09% sodium azide|
|Spn; Sialophorin; Leukosialin; Ly-48; Ly48; Galgp; LEUK|
|Mouse Plasmacytoma MOPC-315|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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