CD45RA Rat anti-Mouse, PerCP-Cy5.5, Clone: 14.8, BD
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 564359
The 14.8 clone has been reported to react with an exon A-dependent epitope of the CD45 protein, which is found at high density on B cells and at low density on peripheral T cytotoxic/suppressor cells and a very small subset of thymocytes. Nearly all B-lineage cells, including B-cell precursors in fetal liver and adult bone marrow and Ig-secreting cells, but not hematopoietic stem cells or myeloid progenitors, have been reported to be detectable by mAb 14.8. CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family: Its intracellular (COOH-terminal) region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons 4, 5, and 6 (designated A, B, and C, respectively), plus, differing levels of glycosylation. The CD45 isoforms detected in the mouse are cell type-, maturation-, and activation state-specific. The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction. mAb 14.8 has been reported to enhance the proliferative effect of PHA on purified spleen T cells, possibly by replacing a signal normally delivered by accessory cells, to enhance isotype switching during in vitro B-cell responses, and to inhibit antigen-induced p21 [ras] activation.
|Aqueous buffered solution containing ≤0.09% sodium azide|
|Ptprc; CD45R; CD45; LCA; Leukocyte common antigen; Ly-5; Lyt-4|
|Radiation-induced NZC mouse B lymphoma WEHI-279|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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