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CD45RB Mouse anti-Human, Non-human primate, FITC, Clone: MEM-55, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119571

Catalog No. 01-676-301


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Description

Description

This antibody recognizes a siliadase-sensitive epitope of CD45RB, a 180-240 kDa single chain type I membrane glycoprotein, variant of CD45 (CD45RB isoform).

CD45RB is a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, but share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RB is expressed in microglia and inflammatory cells. In addition to involvement in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is involved in DNA fragmentation during apoptosis. CD45 is expressed on cells of the human hematopoietic lineage with the exception of mature red cells.
Specifications

Specifications

CD45RB
Monoclonal
FITC
PTPRC
Liquid
PTPRC
Human thymocytes and T lymphocytes.
Purified
RUO
Antibody
Monoclonal
Human, Non-human Primate
Flow Cytometry
MEM-55
PBS with 0.2% BSA and 15mM sodium azide
P08575
B220, CD45, CD45R, GP180, LCA, LY5, T200
Mouse
IgG1
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
5788
Documents
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