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CD45RO Mouse anti-Human, Clone: UCHL1, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119452

Catalog No. 01-676-187


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Description

Description

Pretreatment note: MA1-19452 does not require protein digestion pretreatment of paraffin sections and does not require antigen retrieval using heat treatment prior to staining of paraffin sections. A suggested positive control for this product is tonsil tissue.

CD45RO (UCHL1, ubiquitin carboxyl terminal esterase L1) is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RO is expressed on macrophages, CD8+ T cells, activated T cells and myeloma cells. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
Specifications

Specifications

CD45RO
Monoclonal
1 mg/mL
PBS with 15mM sodium azide; pH 7.4
P08575
B220, CD45, CD45R, GP180, LCA, LY5, T200
Mouse
IgG2a
100 μg
4° C, do not freeze
Primary
5788
Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation
UCHL1
Unconjugated
PTPRC
Liquid
PTPRC
Human IL-2 dependent T cells.
Protein G
RUO
Antibody
Monoclonal
Human
Documents
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