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CD46 Mouse anti-Human, Clone: M177, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA140183
MA1-40183 detects CD46 from human samples. MA1-40183 has been successfully used in flow cytometry, immunoprecipitation, functional assays, immunohistochemistry (frozen) and Western blot applications. The MA1-40183 immunogen is purified MCP. Endotoxin <24 EU/mg. Positive control: CD46 is expressed on every cell and tissue; Negative control: Erythrocytes.CD46, also designated membrane cofactor protein, is a 45-70 kDa protein with genetic and tissue-specific heterogeneity. It is expressed on every cell and tissue, with the exception of erythrocytes. CD46 serves to down-regulate the activation of complement on host tissue. It performs this function by serving as a cofactor which binds to C3b and C4b. This binding is permitted by factor I, a serine protease of plasma, to degrade C3b and C4b and serves to protect the host cell against autologous attack. It also serves as a receptor for measles virus. Four isoforms of CD46 predominate and arise by alternative splicing of a single CD46 gene. The isoforms differ in the length. CD46 cDNA encodes a signal sequence followed by four complement control protein domains (also called short consensus repeats (SCR)). The monoclonal antibody M177 reacts with the SCR2 domain.
|PBS with 0.1% BSA and no preservative|
|AHUS2, MCP, MGC26544, MIC10, TLX, TRA2.10|
|ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot|
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