CD46 Mouse anti-Bovine, Human, Clone: MEM-258, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119018
CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.Western blot should be performed under non-reducing conditions.
|PBS with no preservative; pH 7.4|
|AHUS2, MCP, MGC26544, MIC10, TLX, TRA2.10|
|4° C, do not freeze|
|Flow Cytometry, Immunoprecipitation, Western Blot|
|T cell line HPB-ALL.|
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