CD47 Mouse anti-Human, Non-human primate, Porcine, Clone: MEM-122, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119117
This antibody is purified from ascites by CHT-chromatagraphy and precipitation methods.CD47 (integrin-associated protein, IAP) is a ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins. Functionally, CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. CD47 is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. CD47 has broad tissue distribution, is reduced in expression on Rh erythrocytes. CD47 acts as a ligand for CD172a (signal regulatory protein alpha, SIRP alpha), an immune inhibitory receptor on macrophages; this interaction prevents phagocytosis of CD47-positive cells. Moreover, CD47-CD172a system affects cell migration, B cell adhesion, T cell activation, and is involved in modulation of chondrocyte responses to mechanical signals, and promotes neuronal development, being especially abundant in synapse-rich regions of brain and retina.
|TBS with 15mM sodium azide; pH 8|
|IAP, MER6, OA3, CD47 antigen, CD47 glycoprotein, Rh-related antigen, leukocyte surface antigen CD47|
|4° C, do not freeze|
|Flow Cytometry, Immunohistochemistry (Frozen), Western Blot|
|COS-7 (African green monkey) cells.|
|Human, Non-human Primate, Porcine|
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