CD48 Hamster anti-Mouse, NA/LE, Unlabeled, Clone: HM48-1, BD

Hamster Monoclonal Antibody

Supplier:  BD Biosciences 553682

Catalog No. BDB553682

Description

The HM48-1 monoclonal antibody specifically binds to CD48 (previously known as BCM1 in mice, Blast-1 in human, and OX-45 in the rat), a GPI-anchored member of the Ig superfamily. It is widely distributed on leukocytes, but not on non-hematopoietic cells, and its ligands include CD2 (LFA-2) and CD244 (2B4 antigen). The HM48-1 mAb blocks binding of soluble CD2 to CD48-bearing cells, blocks the interaction of CD2 and CD244, inhibits spleen cell proliferative responses to mitogens, augments the proliferative response of spleen cells when cross-linked with anti-CD3e mAbs, and inhibits priming of CTL in vitro. In vivo administration of HM48-1 antibody can prolong survival of cardiac allografts, an effect which is greatly enhanced by the addition of anti-CD2 mAb 12-15. This hamster mAb to a mouse leukocyte antigen does not cross-react with rat leukocytes.

Specifications

• Antigen: CD48
• Classification: Monoclonal
• Concentration: 1.0mg/mL
• Description: BLAST; BLAST-1; BCM1; HM48-1; MEM-102; Sgp-60; SLAMF2
• Host Species: Hamster
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

• Applications: Flow Cytometry
• Clone: HM48-1
• Conjugate: Unconjugated
• Formulation: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
• Immunogen: Mouse T lymphoma MBL-2
• Quantity: 0.5 mg
• Research Discipline: Immunology
• Target Species: Bovine, Mouse
• Isotype: IgG1

For Research Use Only.