CD49d Mouse anti-Human, Brilliant Violet 421, Clone: 9F10, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 565277
The 9F10 monoclonal antibody specifically reacts with the integrin α 4 chain, that is expressed as a heterodimer with either of two β integrin subunits, β 1 (CD29) or β 7. The α 4β 1 integrin (VLA-4) is expressed on lymphocytes, monocytes, thymocytes, NK cells, and several B- and T-cell lines, and mediates binding to VCAM-1 (CD106) and the CS-1 region of fibronectin. The α β 7 also binds fibronectin and VCAM-1, and has been shown in the mouse to preferentially bind the mucosal vascular addressin molecule, MAdCAM-1. This antibody is useful for studies of the expression by and function of cells that express α 4 chain-containing integrins. This clone cross-reacts with a subset of peripheral blood lymphocytes, monocytes, and some granulocytes of baboon and both rhesus and cynomolgus macaque monkeys. The distribution on leukocytes is similar to that observed with human peripheral blood leukocytes.
|Integrin α4 chain; Integrin alpha 4; ITGA4; IA4; alpha 4 subunit of VLA-4|
|Baboon, Canine, Cynomolgus, Human, Rhesus Monkey|
|Brilliant Violet 421|
|Aqueous buffered solution containing BSA and ≤0.09% sodium azide|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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