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CD49D Mouse anti-Human, PerCP-Cy5.5, Clone: 9F10, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 563644

Catalog No. BDB563644


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Description

Description

The 9F10 monoclonal antibody specifically reacts with the integrin α 4 chain, that is expressed as a heterodimer with either of two β integrin subunits, β 1 (CD29) or β 7. The α 4β 1 integrin (VLA-4) is expressed on lymphocytes, monocytes, thymocytes, NK cells, and several B- and T-cell lines, and mediates binding to VCAM-1 (CD106) and the CS-1 region of fibronectin. The α β 7 also binds fibronectin and VCAM-1, and has been shown in the mouse to preferentially bind the mucosal vascular addressin molecule, MAdCAM-1. This antibody is useful for studies of the expression by and function of cells that express α 4 chain-containing integrins. This clone cross-reacts with a subset of peripheral blood lymphocytes, monocytes, and some granulocytes of baboon and both rhesus and cynomolgus macaque monkeys. The distribution on leukocytes is similar to that observed with human peripheral blood leukocytes.

Specifications

Specifications

CD49d
9F10
Integrin α4 chain; Integrin alpha 4; ITGA4; IA4; alpha 4 subunit of VLA-4
Affinity Purified
IgG1, κ
RUO
Primary
Baboon, Bovine, Canine, Cynomolgus, Human, Rhesus
Flow Cytometry
PerCP-Cyanine5.5
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Murine
50 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
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