ICAM-3 Mouse anti-Human, Clone: MEM-04, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119030
DescriptionCD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes, that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin. Besides functioning as an adhesive molecule that mediates e.g. the contact between T cells and antigen presenting cells, ICAM-3 regulates affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation. ICAM-3 plays an essential role in the initiation of the immune response both on T cells and antigen presenting cells and interacts also with CD209 (dendritic cell-specific ICAM-3-grabbing nonintegrin, DC-SIGN), a C-type lectin of dendritic cells and macrophages; this process is involved in dialogue between dendritic cells and granulocytes.
|PBS with no preservative; pH 7.4|
|CD50, CDW50, ICAM-R, ICAM-3, intercellular adhesion molecule-3|
|4° C, do not freeze|
|Flow Cytometry, Functional Assay, Immunohistochemistry (Paraffin)|
|Leukocytes from a patient suffering from LGL type leukemia.|
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