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ICAM-3 Mouse anti-Human, Clone: MEM-171, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119191

Catalog No. 01-675-955


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Description

Description

This antibody recognizes an epitope in the D2 domain of CD50 (ICAM-3), a 120-130 kDa type I membrane protein (immunoglobulin supergene family) expressed on leukocytes, endothelial cells and Langerhans cells; it is negative on platelets and erythrocytes.

CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes, that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin. Besides functioning as an adhesive molecule that mediates e.g. the contact between T cells and antigen presenting cells, ICAM-3 regulates affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation. ICAM-3 plays an essential role in the initiation of the immune response both on T cells and antigen presenting cells and interacts also with CD209 (dendritic cell-specific ICAM-3-grabbing nonintegrin, DC-SIGN), a C-type lectin of dendritic cells and macrophages; this process is involved in dialogue between dendritic cells and granulocytes.
Specifications

Specifications

ICAM-3
Monoclonal
Unconjugated
ICAM3
Liquid
ICAM3
Human granulocytes.
Protein A
RUO
Antibody
Monoclonal
Human
Flow Cytometry, Immunoprecipitation
MEM-171
PBS with 15mM sodium azide; pH 7.4
P32942
CD50, CDW50, ICAM-R, ICAM-3, intercellular adhesion molecule-3
Mouse
IgG1
100 μg
4° C, do not freeze
Primary
3385
Documents
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