CD53, clone: MEM-53, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119010
CD53 is a tetraspanin family transmembrane glycoprotein expressed in the lymphoid-myeloid lineage. This molecule has been reported to form complexes with other leukocyte surface proteins such as CD2, CD19, CD21, MHC II, VLA-4 or tetraspanins CD37, CD81 and CD82, thus probably modulating various signaling processes. CD53 is involved in radioresistancy of tumour cells and its triggering has anti-apoptotic effect. In thymus, CD53 is up-regulated in response to positive selection signals during T cell development, and is strongly expressed upon macrophage exposure to bacterial lipopolysaccharide, whereas stimulation of neutrophils results in down-regulation of CD53 expression.This antibody reacts with CD53, a 32-40kDa glycoprotein, and also This antibody reacts with the deglycosylated molecule (molecular weight of the antigen is reduced by 15kDa using endoglycosidase F).
|PBS with no preservative; pH 7.4|
|MOX44, TSPAN25, CD53 antigen, CD53 glycoprotein, CD53 tetraspan antigen|
|4° C, do not freeze|
|Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot|
|Leucocytes from a patient suffering from a LGL type leukaemia.|
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