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CD53, clone: MEM-53, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119010

Catalog No. 01-674-983

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

CD53 is a tetraspanin family transmembrane glycoprotein expressed in the lymphoid-myeloid lineage. This molecule has been reported to form complexes with other leukocyte surface proteins such as CD2, CD19, CD21, MHC II, VLA-4 or tetraspanins CD37, CD81 and CD82, thus probably modulating various signaling processes. CD53 is involved in radioresistancy of tumour cells and its triggering has anti-apoptotic effect. In thymus, CD53 is up-regulated in response to positive selection signals during T cell development, and is strongly expressed upon macrophage exposure to bacterial lipopolysaccharide, whereas stimulation of neutrophils results in down-regulation of CD53 expression.

This antibody reacts with CD53, a 32-40kDa glycoprotein, and also This antibody reacts with the deglycosylated molecule (molecular weight of the antigen is reduced by 15kDa using endoglycosidase F).
Specifications

Specifications

CD53
Monoclonal
1mg/mL
PBS with no preservative; pH 7.4
P19397
MOX44, TSPAN25, CD53 antigen, CD53 glycoprotein, CD53 tetraspan antigen
Murine
IgG1
100μg
4° C, do not freeze, do not freeze
Primary
963
Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
MEM-53
Unconjugated
CD53
Liquid
CD53
Leucocytes from a patient suffering from a LGL type leukaemia.
Protein A
RUO
Antibody
Monoclonal
Human
Documents
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