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ICAM-1 Mouse anti-Human, PE, Clone: 1H4, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119663

Catalog No. 01-676-690


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Description

Description

ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.
Specifications

Specifications

ICAM-1
Monoclonal
PE
ICAM1
Liquid
ICAM1
Raji cells and spleen cells fused with NS1 cells.
Size-exclusion chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
1H4
PBS with 0.2% BSA and 15mM sodium azide
P05362
BB2, P3.58, ICAM-1, cell surface glycoprotein P3.58, intercellular adhesion molecule 1, human rhinovirus receptor, major group rhinovirus receptor
Mouse
IgG2b
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
3383
Documents
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