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CD59 Mouse anti-Human, APC, Clone: MEM-43, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119463

Catalog No. 01-676-198


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Description

Description

CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). CD59 is the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 also associates with C5b-8 complex and counteracts appropriate formation of cytolytic pore within the plasma membrane. Further, CD59 is a low-affinity ligand of human CD2, causes T cell costimulation, and is involved in lymphocyte signal transduction. CD59 is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. Mutations in this gene cause CD59 deficiency, a disease involving hemolytic anemia, thrombosis, and cerebral infarction. Multiple alternatively spliced transcript variants of CD59 have been identified.
Specifications

Specifications

CD59
Monoclonal
APC
CD59
Liquid
CD59
Thymocytes and T lymphocytes.
Purified
RUO
Antibody
Monoclonal
Human
Flow Cytometry
MEM-43
PBS with 0.2% BSA and 15mM sodium azide
P13987
CD59, CD59 molecule complement regulatory protein, 1F5, EJ16, EJ30, EL32, G344, MIN1, MIN2, MIN3, MIRL, HRF20, MACIF, MEM43, MIC11, MSK21, 16.3A5, HRF-20, MAC-IP, p18-20
Mouse
IgG2a
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
966
Documents
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