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Transferrin Receptor Mouse anti-Human, Clone: BGX.24, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112156

Catalog No. 01-670-875


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Description

Description

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.

Specifications

Specifications

Transferrin Receptor
Monoclonal
0.5 mg/mL
PBS with 0.08% sodium azide
P02786
CD71, T9, TFR, TFR1, TR, TRFR, p90, transferrin receptor protein 1
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
7037
Flow Cytometry
BGX.24
Unconjugated
TFRC
Liquid
TFRC
Blast cells from pokeweed mitogen-stimulated peripheral blood cells
Protein A/G
RUO
Antibody
Monoclonal
Human
Documents
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