Transferrin Receptor Mouse anti-Human, FITC, Clone: BGX.24, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA112157
DescriptionCellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregcy, irritable bowel syndrome and in HIV patients.
|Blast cells from pokeweed mitogen-stimulated peripheral blood cells|
|PBS with 0.2% carrier protein and 0.08% sodium azide|
|CD71, T9, TFR, TFR1, TR, TRFR, p90, transferrin receptor protein 1|
|4° C, do not freeze|
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