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CD72 Mouse anti-Human, Clone: 3F3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119248

Catalog No. 01-676-012


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Description

Description

CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.
Specifications

Specifications

CD72
Monoclonal
1 mg/mL
PBS with 15mM sodium azide; pH 7.4
P21854
RP11-331F9.9, CD72b, LYB2
Mouse
IgG2b
100 μg
4° C, do not freeze
Primary
971
Flow Cytometry, Immunoprecipitation
3F3
Unconjugated
CD72
Liquid
CD72
Normal human lymphocytes from a lymph node.
Ion-exchange chromatography
RUO
Antibody
Monoclonal
Human
Documents
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