CD72 Mouse anti-Human, Clone: 3F3, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119248
DescriptionCD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.
|PBS with 15mM sodium azide; pH 7.4|
|RP11-331F9.9, CD72b, LYB2|
|4° C, do not freeze|
|Flow Cytometry, Immunoprecipitation|
|Normal human lymphocytes from a lymph node.|
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