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CD8 Mouse anti-Human, APC, Clone: MEM-31, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119455

Catalog No. 01-676-190


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Description

Description

CD8 (Cluster of Differentiation 8) is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediate efficient cell-cell interactions within the immune system. The CD8 antigen acts as a co-receptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. CD8 is found on a T cell subset of normal cytotoxic/suppressor cells which make up approximately 20-35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer (NK) cells, subpopulations of peripheral blood null cells, thymocytes and bone marrow cells. The CD8 co-receptor functions as either a homodimer composed of two alpha chains, or as a disulfide-linked heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. The majority of CD8+ T cells express CD8 as a alpha/beta heterodimer. In HIV, the HIV-2 envelope glycoprotein binds CD8 alpha chain (but not the beta chain).
Specifications

Specifications

CD8
Monoclonal
APC
CD8B
Liquid
CD8A, CD8B
Crude thymus membrane fraction.
Purified
RUO
Antibody
Monoclonal
Human
Flow Cytometry
MEM-31
PBS with 0.2% BSA and 15mM sodium azide
P01732, P10966
CD8, Leu-2, MAL, p32, CD8a, CD8b, CD8alpha, CD8beta
Mouse
IgG2a
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
925, 926
Documents
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