CD8/CD28 Mouse anti-Human, FITC, PE, Invitrogen
Manufacturer: Invitrogen MA112166
This antibody is a monoclonal mixture of FITC-conjugated CD8 (clone 17D8, isotype IgG1) and PE-conjugated CD28 (clone B-23, isotype IgG1).CD8 molecule is composed of two chains termed alpha and beta. CD8 is found on a T cell subset of normal cytotoxic / suppressor cells which make up approximately 20 to 35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer cells, 80% of thymocytes, on a subpopulation of 30% of peripheral blood null cells and 15 to 30% of bone marrow cells. Human CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. It is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes (approximately 95% of CD4+ cells and 50% of CD8+ cells). Mature thymocytes exhibit higher levels of CD28 than the immature cells. Activation of T cells results in enhanced CD28 expression. T cell activation requires two combined signals provided by antigen presenting cells.
|CD28, CD8A, CD8B|
|human peripheral blood T lymphocytes and HPB-ALL T-cell line|
|925, 926, 940|
|PBS with 0.2% carrier protein and 0.08% sodium azide|
|P01732, P10747, P10966|
|CD8, Leu-2, MAL, p32, CD8a, CD8b, CD8alpha, CD8beta, MGC138290, Tp44, CD28 antigen, T-cell-specific surface glycoprotein CD28|
|4° C, do not freeze|
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