CD8/CD45RA Mouse anti-Human, FITC, PE, Invitrogen™
Manufacturer: Invitrogen MA112229
This antibody is a monoclonal mixture of FITC-conjugated CD8 (clone 17D8, isotype IgG1) and PE-conjugated CD45RA (clone BHKG-2, isotype IgG1).CD8 molecule is composed of two chains termed alpha and beta. CD8 is found on a T cell subset of normal cytotoxic / suppressor cells which make up approximately 20 to 35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer cells, 80% of thymocytes, on a subpopulation of 30% of peripheral blood null cells and 15 to 30% of bone marrow cells. CD45 Leukocyte Common Antigen (LCA) belongs to the family of at least four isoforms of membrane glycoproteins (220, 205, 190, 180 kDa) expressed on hematopoietic cell lines but absent on non-hematopoietic cell lines, normal and maligt, non-hematopoietic tissues. The intracellular portion of these molecules have protein phosphatase activity and are involved in regulation of transmembrane signals.
|CD8A, CD8B, PTPRC|
|human peripheral blood monocytes from a rheumatoid arthritis patient and human peripheral blood T lymphocytes|
|5788, 925, 926|
|PBS with 0.2% carrier protein and 0.08% sodium azide|
|P01732, P08575, P10966|
|CD8, Leu-2, MAL, p32, CD8a, CD8b, CD8alpha, CD8beta, PTPRC, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, CD45 antigen, T200 glycoprotein, T200 leukocyte common antigen, protein tyrosine phosphatase, receptor type, c polypeptide, receptor-type tyrosine-protein phosphatase C|
|4° C, do not freeze|
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