CD8 Mouse anti-Human, Mouse, Rat, Clone: RIV11, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA17632
MA1-7632 detects CD8 from human, rat and mouse samples. MA1-7632 has been successfully used in ELISA, flow cytometry, immunoprecipitation, and immunohistochemistry (frozen sections) procedures. The MA1-7632 immunogen is a CD8 protein.CD8 (Cluster of Differentiation 8) is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediate efficient cell-cell interactions within the immune system. The CD8 antigen acts as a co-receptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. CD8 is found on a T cell subset of normal cytotoxic/suppressor cells which make up approximately 20-35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer (NK) cells, subpopulations of peripheral blood null cells, thymocytes and bone marrow cells. The CD8 co-receptor functions as either a homodimer composed of two alpha chains, or as a disulfide-linked heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. The majority of CD8+ T cells express CD8 as a alpha/beta heterodimer. In HIV, the HIV-2 envelope glycoprotein binds CD8 alpha chain (but not the beta chain).
|PBS with 0.01% sodium azide; pH 7.2|
|P01732, P10966, P01731, P05541, P07725|
|CD8, Leu-2, MAL, p32, CD8a, CD8b, CD8alpha, CD8beta|
|4°C or -80°C if preferred|
|12525, 24930, 24931, 925, 926|
|ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation|
|Human, Mouse, Rat|
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