CD80 Mouse anti-Human, FITC, Clone: BB1, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 555683

Catalog No. BDB555683

Description

Reacts with a 60kDa transmembrane glycoprotein which was clustered as CD80 in the Fifth International Workshop on Human Differentiation Antigens. There have been several recent studies reporting discrepancies in the expression and function of CD80 when the BB1 clone is used compared to other anti-CD80 monoclonals (e.g., L307.4). Caution should therefore be used in the interpretation of data generated using BB1, as reports indicate that BB1 may recognize, in addition to CD80, CD74 and even possibly another as yet undefined molecule. CD80, a member of the Ig supergene family, is expressed on activated B cells, macrophages, and dendritic cells. It is the ligand for two molecules expressed on T cells: CD28 and CD152 (CTLA-4). CD80 is also expressed in activated CD4+ and CD8+ T cells, appearing late after activation, suggesting that activated T cells may be capable of autocrine costimulation via the CD28 activation pathway. The binding of CD28 molecule by CD28 mAb or by CD80 antigen results in T-cell activation and a signal for IL-2 production.

Host Species: Mouse
Clone: BB1
Isotype: IgM, κ
Species Reactivity: Human

Flow Cytometry

Specifications

• Antigen: CD80
• Classification: Monoclonal
• Conjugate: FITC
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Applications: Flow Cytometry
• Clone: BB1
• Description: B7-1
• Host Species: Mouse
• Quantity: 100 Tests
• Research Discipline: Immunology
• Target Species: Human
• Isotype: IgM κ

For Research Use Only.