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CD8b Mouse anti-Human, PE, Clone: 2ST8.5H7, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 641057

Catalog No. BDB641057


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Description

Description

The CD8β antibody, clone 2ST8.5H7, is derived from the hybridization NS-1 mouse tumor cells with splenocytes from Balb/c mice immunized with CD8+ suppressor T-cell clone termed 20a6.

The CD8β antibody recognizes an epitope formed by the combination of CD8 alpha and beta chains. The majority of peripheral blood CD8+ T lymphocytes expresses an α/β heterodimer (32, 30 kilodaltons (kDa)), while CD8+CD16+ natural killer (NK) lymphocytes and CD8+ T-cell receptor (TCR)-γ/δ NK cells. The CD8 antigenic determinant binds to class I major histocompatibility (MHC) molecules, resulting in increased adhesion between the CD8+ T lymphocytes and target cells. Binding of the CD8 antigen to class I MHC molecules enhances the activation of resting T lymphocytes. The CD8 antigen is coupled to a protein tyrosine kinase, p56lck. The CD8:p56lck complex can play a role in T-lymphocyte activation through mediation of the interactions between the CD8 antigen and the CD3/TCR complex.

Specifications

Specifications

CD8b
2ST8.5H7
PE
Affinity Purified
CD8
50 Tests
Store vials at 2-8°C. Conjugated forms should not be frozen and should be protected from prolonged exposure to light. Each reagent is stable for the period shown on the bottle label when stored as directed.
Monoclonal
Flow Cytometry
6μg/mL
Phosphate buffered saline with gelatin and 0.1% sodium azide.
Murine
IgG2a, κ
RUO
Primary
Human
Documents
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