CD9 Rat anti-Mouse, Alexa Fluor 647, Clone: KMC8, BD
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 564233
The KMC8 monoclonal antibody specifically binds to CD9 which is also known as Tetraspanin-29 (Tspan29). CD9 is a 24-kDa member of the transmembrane 4 superfamily, also called the tretraspanin family. In the mouse, CD9 is present on bone marrow myeloid cells, stromal cells, and megakaryocyte-committed progenitors; subsets of peripheral T and B lymphocytes; and neutrophils, platelets, dendritic cells, and bone marrow-derived macrophages. CD9 has been found to be associated with integrins and other cell-surface receptors. It appears to play roles in signal transduction and in regulating cellular adhesive properties. CD9 can also reportedly participate in T-cell costimulation and induction of apoptosis. The KMC8 antibody reportedly blocks certain CD9 functions and activates macrophages.
|Alexa Fluor 647|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Cd9; Tetraspanin-29; Tspan29|
|(C57BL/6 x DBA/2)F1 mouse bone marrow-derived stromal cell line BMS2|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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