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CD95 Mouse, Unlabeled, Clone: 13, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610198

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Catalog No. BDB610198


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Description

Description

CD95 is a member of a family of cell surface receptors that includes tumor necrosis factor receptor (TNF-R), nerve growth factor receptor (NGF-R), CD40, CD27, CD30, and 4-1BB. Both murine and human Fas genes have been cloned and reportedly share 60% similarity in their amino acid sequences. CD95 (Fas) is a cell surface apoptosis-signaling molecule that is widely expressed in sites such as thymus, liver, heart, and ovary. Abnormalities in the Fas gene correlate with autoimmune features in mice and with unusually high levels of lymphocyte apoptosis in HIV-infected humans. Genetic studies have localized the Fas gene near the lpr (lymphoproliferation disease) locus on mouse chromosome 19 and further characterization reportedly has revealed that lpr is a mutation affecting the function of the Fas gene.

Specifications

Specifications

CD95
13
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG2a, κ
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
Fas, APO-1
Affinity Purified
Aqueous buffered solution containing BSA
150μg
Cell Biology
Primary
Canine, Chicken, Human, Murine, Rat
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