FAS Mouse anti-Human, Clone: UT-1, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119024
CD95 (Fas, APO-1), a 46kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses.
|T cell lymphoma cells HUT-78.|
|Flow Cytometry, Functional Assay, Western Blot|
|HEPES buffered saline with no preservative; pH 7.0|
|ALPS1A, APO-1, APT1, Apo-1 Fas, CD95, FAS1, FASTM, TNFRSF6|
|4° C, do not freeze|
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