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FAS Mouse anti-Human, Clone: UT-1, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119024

Catalog No. 01-674-997


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Description

Description

CD95 (Fas, APO-1), a 46kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses.

Specifications

Specifications

FAS
Monoclonal
1 mg/mL
Assay Dependent
FAS
Liquid
FAS
T cell lymphoma cells HUT-78.
Ion-exchange chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry, Functional Assay, Western Blot
UT-1
Unconjugated
HEPES buffered saline with no preservative; pH 7.0
P25445
ALPS1A, APO-1, APT1, Apo-1 Fas, CD95, FAS1, FASTM, TNFRSF6
Mouse
IgM
100 μg
4° C, do not freeze
Primary
355
Documents
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