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CDC5L Mouse, Unlabeled, Clone: 21, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 612362

Catalog No. BDB612362

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Splicing, the removal of introns from pre-mRNA, is mediated by spliceosomal complexes and occurs in two distinct catalytic steps. The first step involves cleavage of the 5′ exon and the production of a lariat intermediate. In the second step, the 3′-splice site is cleaved and the exons are fused with concomitant release of the intron lariat. The spliceosome contains multiple snRNPs and a number of non-snRNP splicing factors. CDC5L is a non-snRNP component of the splicesome that is homologous to the yeast Cdc5 protein. The sequence for CDC5L contgains a helix-turn-helix DNA binding domain (DBD), four nuclear localization signals, and a hydrophilic, proline-rich central region that is similar to the transcriptional activating domain in Myb family transcription factors. CDC5L can interact with the nuclear PP1 inhibitor NIPP-1 and the WD40 domain protein PLRG1. Both of these interactions are critical for pre-mRNA splicing and may also be important for G 2/M phase transition. In addition, CDC5L translocates from the cytoplasm to the nucleus in the presence of serum. Thus, CDC5L localization and splicesome-regulating activity may be controlled by mitogen-activated signal transduction pathways.

Bioimaging, Immunofluorescence, Western Blotting



Affinity Purified
Rat CDC5L aa. 109-303
Cell Biology
Canine, Chicken, Human, Murine, Rat
Western Blot
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Store undiluted at -20°C.
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