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CDIP1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520697

Catalog No. PIPA520697


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Description

Description

A suggested positive control is human brain tissue lysate. PA5-20697 can be used with blocking peptide PEP-0812.

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers. CDIP is a novel pro-apoptotic target gene whose inhibition abrogates p53-mediated apoptotic responses. Overexpression of CDIP induced apoptosis in transfected cells while siRNA suppression of caspase-8 mRNA blocked this CDIP-induced apoptosis, indicating that the CDIP-dependent apoptosis pathway proceeds through extrinsic cell death pathway. CDIP may thus represent a novel target for drug design to maximize p53 response and sensitize tumor cells to cancer therapy. Multiple isoforms of CDIP are known to exist.
Specifications

Specifications

CDIP1
Polyclonal
Unconjugated
CDIP1
Liquid
CDIP1
A 19 amino acid peptide near the center of human CDIP.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9H305, Q9DB75
CDIP, I1; LITAF-like protein; cell death inducing protein; cell death-inducing protein; transmembrane protein I1
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
29965, 66626
Documents
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