CDK7 Mouse anti-Human, Clone: MO-1, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA112300
DescriptionCdk7 is the catalytic subunit of the CDK-activating kinase (CAK) complex, a serine-threonine kinase. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive carboxyl-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Cdk7 is involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
|Recombit 221 residues fragment of the C-terminus of p40.|
|Ammonium Sulfate Precipitation|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot|
|PBS with 0.08% sodium azide|
|EC 126.96.36.199, EC 188.8.131.52, CDK-activating kinase, CAK, TFIIH basal transcription factor complex kinase subunit|
|-20° C, Avoid Freeze/Thaw Cycles|
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