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CDK7 Mouse anti-Human, Clone: MO-1, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112300

Catalog No. 01-670-993


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Description

Description

Cdk7 is the catalytic subunit of the CDK-activating kinase (CAK) complex, a serine-threonine kinase. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive carboxyl-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Cdk7 is involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
Specifications

Specifications

Cdk7
Monoclonal
Unconjugated
CDK7
Liquid
CDK7
Recombit 221 residues fragment of the C-terminus of p40.
Ammonium Sulfate Precipitation
RUO
Antibody
Monoclonal
Human
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
MO-1
PBS with 0.08% sodium azide
P50613
EC 2.7.11.22, EC 2.7.11.23, CDK-activating kinase, CAK, TFIIH basal transcription factor complex kinase subunit
Mouse
IgG2b
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
1022
Documents
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