CDK8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA121780
PA1-21780 detects Cdk8 in Human, Rat and Mouse samples. PA1-21780 has been successfully used in ChIP, Immunofluorescence, Immunoprecipitation and Western Blot procedures. PA1-21780 immunogen corresponds to Synthetic peptide: C-SQQPPQYSHQTHRY, corresponding to amino acids 451-464 of Human Cdk8..A family of proteins designated as cdks are critical regulators of cell cycle progression. The prototype member of this family, p34 / Cdc 2, and a related protein Cdk 2, function late in the cycle while Cdk 4 and Cdk 6 are critically involved in G1 to S progression. The p54 / Cdk 8 interacts exclusively with Cyclin C. The Cdk 8 Cyclin C complex activates the kinase. Because of analogy with yeast Cdk 8, it has been proposed that the human Cdk 8 Cyclin C may interact with RNA polymerase, thus influencing the transcription mechanism(s) that lead to cell division.
|Synthetic peptide: C-SQQPPQYSHQTHRY, corresponding to amino acids 451-464 of Human Cdk8.|
|Human, Mouse, Rat|
|ChIP assay, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot|
|10mM PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4|
|K35, MGC126074, MGC126075|
|4° C, do not freeze|
|1024, 264064, 498140|
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