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CDK8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA121780

Catalog No. PIPA121780


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Description

Description

PA1-21780 detects Cdk8 in Human, Rat and Mouse samples. PA1-21780 has been successfully used in ChIP, Immunofluorescence, Immunoprecipitation and Western Blot procedures. PA1-21780 immunogen corresponds to Synthetic peptide: C-SQQPPQYSHQTHRY, corresponding to amino acids 451-464 of Human Cdk8..

A family of proteins designated as cdks are critical regulators of cell cycle progression. The prototype member of this family, p34 / Cdc 2, and a related protein Cdk 2, function late in the cycle while Cdk 4 and Cdk 6 are critically involved in G1 to S progression. The p54 / Cdk 8 interacts exclusively with Cyclin C. The Cdk 8 Cyclin C complex activates the kinase. Because of analogy with yeast Cdk 8, it has been proposed that the human Cdk 8 Cyclin C may interact with RNA polymerase, thus influencing the transcription mechanism(s) that lead to cell division.
Specifications

Specifications

Cdk8
Polyclonal
Unconjugated
CDK8
Liquid
CDK8
Synthetic peptide: C-SQQPPQYSHQTHRY, corresponding to amino acids 451-464 of Human Cdk8.
Protein A
RUO
Antibody
Polyclonal
Human, Mouse, Rat
ChIP assay, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
0.2 mg/mL
10mM PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
P49336, Q8R3L8
K35, MGC126074, MGC126075
Rabbit
IgG
500 μL
4° C, do not freeze
Primary
1024, 264064, 498140
Documents
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