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p27 Kip1 Mouse anti-Canine, Human, Mouse, Rat, Clone: DCS72, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112302

Catalog No. 01-670-995


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Description

Description

In immunoprecipitation applications, CDK4 has been found to co-precipitate.

p27 Kip1 functions as a negative regulator of G1 mouse expression and has been proposed to function as a possible mediator of TGFb induced G1 arrest. p27 Kip1 is an important regulator of cell cycle progression, a potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. p27 Kip1 forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. p27 Kip1 acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. p27 Kip1 has a molecular weight of approximately 27kDa and the degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
Specifications

Specifications

p27 Kip1
Monoclonal
1 mg/mL
PBS with 0.08% sodium azide
Q6SLL5, P46527, P46414
CDKN4, KIP1, CDKN1B
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
1027, 12576, 403429, 83571
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
DCS72
Unconjugated
CDKN1B
Liquid
CDKN1B
His-tagged recombit full-length mouse p27
Protein A/G
RUO
Antibody
Monoclonal
Canine, Human, Mouse, Rat
Documents
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