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p16INK4a Goat anti-Human, Polyclonal, Invitrogen™

Goat Polyclonal Antibody

Manufacturer:  Invitrogen PA19025

Catalog No. 01-674-609


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Description

Description

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
Specifications

Specifications

p16INK4a
Polyclonal
Unconjugated
CDKN2A
Liquid
CDKN2A
Synthetic peptide corresponding to the C terminus amino acids HARIDAAEGPSDIPD.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry, peptide-ELISA, Western Blot
0.5 mg/mL
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
P42771
CDKN2A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) ; HGNC:1787; ARF; CDK4I; CDKN2; CMM2; INK4; INK4a; MLM; MTS1; TP16; p14; p
Goat
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
1029
Documents
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