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CDKN2B Mouse anti-Human, Clone: DCS114.1, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112294

Catalog No. 01-670-987


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Description

Description

The four known 15-to 19 kDa INK4 proteins (p15INK4b, p16INK4a, p18INK4c andp19INK4d) bind and inhibit CDK4 and CDK6 but not other CDKs, including cyclin E-Cdk2, cyclin A-Cdk2 and cyclin B-Cdk1. Like the three D-type cyclins, the INK4 genes are expressed in distinct tissue-specific patterns, suggesting that they are not strictly redundant. 5 p18INK4c is expressed during G1 to S transition in the eukaryotic cell division cycle. It is maximally induced as cells enter S-phase. The availability of a monoclonal antibody reacting specifically with p18INK4c enables the subcellular detection and localization of p18INK4c and the measurement of relative differences in p18INK4c levels as a function of cell cycle phase.
Specifications

Specifications

CDKN2B
Monoclonal
Unconjugated
CDKN2B
Liquid
CDKN2B
His-tagged recombit full length p15 protein.
Protein A/G
RUO
Antibody
Monoclonal
Human
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
DCS114.1
PBS with 0.08% sodium azide
P42772
CDK4I, INK4B, MTS2, P15, TP15, p15INK4b
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
1030
Documents
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