CDNF Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520429
A suggested positive control is mouse brain tissue lysate. PA5-20429 can be used with blocking peptide PEP-0546.The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neuro-trophic factor. Somewhat surprisingly, CDCF is expressed at higher levels in tissues such as heart, skeletal muscle and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxylamine (6-OHDA)-induced degeneration of dopaminergic neurons in a rat model of Parkinson’s disease. Furthermore, CDNF was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in the substantia nigra, suggesting that CDNF might be suitable for the treatment of Parkinson’s disease. At least two isoforms of CDNF are known to exist.
|a 9 amino acid peptide from near the carboxy terminus of human CDNF.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|Q49AH0, Q8CC36, P0C5I0|
|ARMETL1; ARMET-like protein 1; arginine-rich, mutated in early stage tumors-like 1; conserved dopamine neurotrophic factor|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|227526, 361276, 441549|
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