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CDX2 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA513122

Catalog No. PIPA513122

Item Discontinued This item has been discontinued by the supplier and is no longer available. Please reach out to your sales representative.


Description

Description

This antibody is predicted to react with mouse based on sequence homology.

The caudal type homeo box transcription factors 1 (CDX1) and 2 (CDX2) are candidates for directing intestinal development, differentiation, and maintece of the intestinal phenotype. CDX1 and CDX2 expression is widely present in the human intestinal and colonic mucosae, but not in the gastric mucosa, suggesting a possible role in the terminal differentiation of the intestine. Increased CDX2 expression is associated with chronic atrophic gastritis. Detectable expression of CDX2 precedes expression of CDX1 during the progression of intestinal metaplasia, thus expression of CDX2 may trigger the initiation and development of intestinal metaplasia. Markedly reduced or absent CDX2 expression was noted by immunohistochemistry in 13 of 15 (87%) large cell minimally differentiated carcinomas (LCMDCs), whereas only 1 of the 25 (4%) differentiated adenocarcinomas (DACs) showed reduced CDX2 expression. Thus, a significant decrease in human CDX1 and/or CDX2 expression may be associated with colorectal tumorigenesis.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

CDX2
Polyclonal
CDX2
CDX2
KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CDX2
400 μL
Primary
Human
Antibody
IgG
Immunohistochemistry, Western Blot
Unconjugated
Q99626
Rabbit
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
1045
-20° C, Avoid Freeze/Thaw Cycles
Liquid
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