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CEACAM1 Mouse anti-Human, Clone: 283324, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA523908

Catalog No. PIMA523908


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Description

Description

In ELISAs and Western blots, no cross-reactivity with recombit human (rh) CD31, rhICAM-1, -2, -3, recombit mouse MAdCAM-1, or rhVCAM-1 was observed. In sandwich ELISAs, no cross-reactivity with rhCEACAM-3, rhCEACAM-5, or rhCEACAM-6 was observed. Reconstitute at 0.5 mg/mL in sterile PBS.

CEACAM1 (BGP/CD66a) is a transmembrane glycoprotein which belongs to the carcinoembryonic antigen (CEA) gene family. It is expressed on cells of epithelial and myeloid origin and mediates homophilic intercellular interactions that influence cellular growth, immune cell activation, and tissue morphogenesis. CEACAM1 is a putative tumour suppressor based on diminished expression in some aggressive types of cancer cells. The anti-tumour effect may be due to inhibition of tumour angiogenesis, possibly by increased secretion of anti-angiogenic molecules from the cells. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by two immunoglobulin constant-like A (A1, A2) and one B domain. While the N, A1 and B domains can also be found in other CEA-family members, the A2 domain of CEACAM1 differs from those found in other CEACAM.
Specifications

Specifications

CEACAM1
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
P13688
BGP, BGP1, BGPI, CD66a antigen, antigen CD66, carcinoembryonic antigen-related cell adhesion molecule 1
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
634
ELISA, Immunohistochemistry, Western Blot
283324
Unconjugated
CEACAM1
Lyophilized
CEACAM1
Mouse myeloma cell line NS0-derived recombit human CEACAM-1 Gln35-Gly428
Protein A/G
RUO
Antibody
Monoclonal
Human
Documents
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