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Cellugyrin Mouse, Unlabeled, Clone: 24, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611128

Catalog No. BDB611128


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Description

Description

Neurotransmitter release is mediated by the synaptic vesicle cycle at the presynaptic nerve terminal. This exocytic process involves vesicle docking at the plasma membrane, which is followed by priming and fusion. Following exocytosis, the empty vesicles are recycled for continued neurotransmitter release. Vesicle fusion is mediated by a protein complex consisting of both synaptic vesicle and synaptic plasma membrane components, such as synaptotagmin, synaptobrevin, and synaptogyrin. It is thought that synaptic vesicle-mediated exocytosis is very similar to other exocytic pathways. In line with this idea, cellugyrin is a synaptogyrin-like protein that is widely expressed in non-neuronal tissues. Cellugyrin and synaptogyrin share 47% amino acid sequence identity. Additionally, both cellugyrin and synaptogyrin are phosphorylated in their cytoplasmic tails by pp60c-src. This suggests a role for phosphorylation in the regulation of membrane trafficking. Thus, cellugyrin is a ubiquitously expressed exocytic protein of which synaptogyrin is a specialized neuronal version. However, the exact function of either protein in exocytosis remains to be determined.

Host Species: Mouse
Clone: 24
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Rat Cellugyrin aa. 95-204
Formula Weight [Chemical]: 29kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

Cellugyrin
24
Unconjugated
Affinity Purified
Rat Cellugyrin aa. 95-204
50μg
Cell Biology
Primary
Murine, Rat
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Documents
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