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CENPE Mouse anti-Human, Clone: 1H12, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA15758

Catalog No. 01-675-178


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Description

Description

This target has a predicted molecular weight of 312 kDa and is only suitable for Western blot if IP is performed first.

The kinetophore is a macromolecular structure that is associated with the centromeres of chromosomes and is responsible for establishing and maintaining the connections with the microtubules of the mitotic spindle. The proteins that reside within the chromosomal domain fall into two broad classes: those that associate with the centromere throughout the cell cycle and those that are found at the centromere in a cell cycle specific manner. Members of the first class include CENP-A, CENP-B, and CENP-C. The members of the second class include several ubiquitous cellular proteins such as calmodulin, tubulin, dynein and p34 cdc2 and also CENP-E and CENP-F. CENP-F appears to be the earliest member to interact with the centromere-kinetochore complex. CENP-F also shows a cell-cycle distribution that is both temporally regulated and diverse in terms of the structural components it localizes to and therefore may play a role in several mitotic events.
Specifications

Specifications

CENPE
Monoclonal
1 mg/mL
PBS with 0.1% sodium azide
Q02224
centromere protein E
Mouse
IgG1, kappa
100 μL
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Primary
1062
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
1H12
Unconjugated
CENPE
Liquid
CENPE
Recombit full length CENP-E protein (human) from SP2/0 cells
Ion-exchange chromatography
RUO
Antibody
Monoclonal
Human
Documents
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