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CENTB1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523343

Catalog No. PIPA523343


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Description

Description

ACAP1, also known as Centaurin-beta-1 (CENTB1), is a 740 amino acid containing transport carrier belonging to the Centaurin family with three ANK repeats, an Arf-GAP domain, a BAR domain and a PH domain that binds to phospholipids. ACAP1, a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6), is required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. It mediates CENTB1-binding to phosphatidylinositol 3,5-bisphosphate (PIP2) or phosphatidylinositol 3,4,5-trisphosphate (PIP3) containing membranes. Along with ACAP2, ACAP1 is recruited to platelet-derived growth factor (PDGF) induced dorsal membrane ruffles in NIH 3T3 mouse fibroblasts, while over expression inhibited ruffle formation. It is widely expressed in most tissues with high expression in lung and spleen and low expression in heart, kidney, liver and pancreas.
Specifications

Specifications

CENTB1
Polyclonal
Unconjugated
ACAP1
Liquid
ACAP1
Synthetic peptide (535 RPRGQPPVPPKPSIR 549) of CENTB1/ACAP1 protein.
Protein A
RUO
Antibody
Polyclonal
Human
Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q15027
CENTB1, Arf GAP with coiled coil, ANK repeat and PH domains 1, arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1, centaurin, beta 1, centaurin-beta-1, cnt-b1
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
9744
Documents
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