ACAP2 Goat anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Goat Polyclonal Antibody
Manufacturer: Invitrogen PA518209
This antibody is predicted to react with canine and porcine based on sequence homology.ACAP2 is a transport carrier belonging to the Centaurin family with three ANK repeats, an Arf-GAP domain, a BAR domain, and a PH domain. ACAP2, a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) has robust constitutive ARF6 GAP activity, where the GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid but has little activity toward ARF1 and is known to control the return of ARF to the inactive GDB-bound shots. ACAP2, along with ACAP1, is targeted by phosphatidyl inositol (3, 4, 3) triphosphate inhibiting the formation of PDGF-induced dorsal membrane ruffles in NIH3T3 fibroblasts when overexpressed. ACAP2 is phosphorylated upon DNA damage, probably by ATM or ATR. Expression is wide-spread with the highest level in lung.
|Synthetic peptide sequence (EKLNRFQQDSQKF) corresponding to the C-terminus amino acids of ACAP2|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunohistochemistry, Western Blot|
|TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3|
|Q15057, Q6ZQK5, Q5FVC7|
|ACAP2; CENTB2; centaurin, beta 2; CNT-B2; KIAA0041; centaurin beta2; Arf GAP with coiled coil, ANK repeat and PH domains 2; ArfGAP with coiled-coil, ankyrin repeat and PH domains 2|
|-20° C, Avoid Freeze/Thaw Cycles|
|23527, 619382, 78618|
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