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CENTG1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA524429

Catalog No. PIPA524429

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

This antibody is predicted to react with rat based on sequence homology.

GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
Specifications

Specifications

CENTG1
Polyclonal
PBS with 0.09% sodium azide
Q99490, Q3UHD9
CENTG1, GGAP2, PIKE, Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2, GTP-binding and GTPase activating protein 2, arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2, centaurin, gamma 1, cnt-g1, phosphatidylinositol-3-kinase enhancer, phosphoinosi
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
116986, 216439
Western Blot
Unconjugated
AGAP2
Liquid
AGAP2
KLH conjugated synthetic peptide between 850-877 amino acids from the C-terminal region of human CENTG1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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