Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Ceruloplasmin Mouse, Unlabeled, Clone: 8, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611488

 View more versions of this product

Catalog No. BDB611488


Add to cart

Description

Description

Ceruloplasmin (CP) is a copper-containing glycoprotein that carries approximately 90% of plasma copper. CP contains six copper atom binding sites and is prone to transfer its copper atoms to tissues, however it is not essential for copper transport. In cultured endothelial cells, CP release of copper in the cytosol inhibits nitric oxide synthase activation, and this may be important for regulating vascular tone in blood vessels. In addition to its copper binding role, CP has also been shown to have ferroxidase activity, which involves conversion of ferrous to
ferric iron. The iron metabolism disorder aceruloplasminemia results from mutations in CP and is characterized by massive iron deposits in liver, pancreas, brain, retina, and other tissues. CP is expressed in the liver, the splenic reticuloendothelial system, the bronchiolar epithelium of the lung, and the retina and brain. The cell-specific expression of CP in neural tissues may account for the neuropathologies associated with aceruloplaminemia, while the wide expression pattern of CP may demonstrate its importance in the regulation of copper and iron levels in many tissues.

Host Species: Mouse
Clone: 8
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Mouse ceruloplasmin aa. 233-355
Formula Weight [Chemical]: 132kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

Ceruloplasmin
8
Unconjugated
Affinity Purified
Mouse ceruloplasmin aa. 233-355
50μg
Cell Biology
Primary
Human, Murine, Rat
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit

For Research Use Only.