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Ceruloplasmin Mouse, Unlabeled, Clone: 8, BD

Mouse Monoclonal Antibody

$207.00 - $415.00


Antigen Ceruloplasmin
Isotype IgG1
Immunogen Mouse ceruloplasmin aa. 233-355
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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BD Biosciences
50μg Each for $207.00
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150μg Each for $415.00
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Ceruloplasmin (CP) is a copper-containing glycoprotein that carries approximately 90% of plasma copper. CP contains six copper atom binding sites and is prone to transfer its copper atoms to tissues, however it is not essential for copper transport. In cultured endothelial cells, CP release of copper in the cytosol inhibits nitric oxide synthase activation, and this may be important for regulating vascular tone in blood vessels. In addition to its copper binding role, CP has also been shown to have ferroxidase activity, which involves conversion of ferrous to
ferric iron. The iron metabolism disorder aceruloplasminemia results from mutations in CP and is characterized by massive iron deposits in liver, pancreas, brain, retina, and other tissues. CP is expressed in the liver, the splenic reticuloendothelial system, the bronchiolar epithelium of the lung, and the retina and brain. The cell-specific expression of CP in neural tissues may account for the neuropathologies associated with aceruloplaminemia, while the wide expression pattern of CP may demonstrate its importance in the regulation of copper and iron levels in many tissues.

Host Species: Mouse
Clone: 8
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Mouse ceruloplasmin aa. 233-355
Formula Weight [Chemical]: 132kDa

Immunofluorescence, Western Blotting



Mouse ceruloplasmin aa. 233-355
Cell Biology
Affinity Purified
Store undiluted at -20°C.
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Western Blot

For Research Use Only.

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